A hospital in southern Israel and two towns near Tel Aviv were struck after a barrage of Iranian missiles on Thursday morning, with rescuers reporting at least 47 people injured in the latest attacks.

Iran escalated its conflict with Israel by launching missiles at the Tel Aviv Stock Exchange, striking a key part of the country's financial sector.

Ayatollah Khamenei has rejected the US president’s ultimatum to surrender and warned against American military intervention

Pakistan will temporarily host 20,000 Iranian pilgrims stranded in Saudi Arabia due to regional airspace closures amid the escalating Iran-Israel conflict. Islamabad has assured all necessary arrangements to accommodate the pilgrims during their stay in Karachi.

Iranian lawmakers publicly praised Pakistan for its support amid rising tensions with Israel, chanting "Thank you, thank you Pakistan" during a parliamentary session.

Israel's massive strikes on Iran, which it calls an existential threat, have hit nuclear and military facilities, killed top commanders and dozens of civilians, and sought to destroy the country's defence capabilities.

Iran called the Israeli air assault "a declaration of war" and fired dozens of missiles at Israel later Friday and Saturday.

Oil prices soared more than 12 percent and stocks sank Friday after Israel launched strikes on Iranian nuclear and military sites and warned of more to come, stoking fears of a full-blown war.

Iran's Revolutionary Guards chief Hossein Salami, who was killed in an Israeli air strike on Tehran Friday, was a veteran officer close to supreme leader Ayatollah Ali Khamenei known for his tirades against Israel and its US ally.

Middle East leaders and their Western allies have been warning that ISIS could exploit the fall of the Assad regime to stage a comeback in Syria and neighbouring Iraq, where the extremist group once imposed a reign of terror over millions.

Iran's top diplomat and chief nuclear negotiator will meet the head of the International Atomic Energy Agency in Cairo on Monday, Egypt's foreign ministry said.

Iran seeks joint uranium enrichment with UAE and Saudi Arabia to ease US pressure and gain Gulf backing for its nuclear programme.