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Saturday, April 13, 2024

Vaccine trials ‘produce immune response’, give hope against COVID-19

Amid the race to find a cure to the novel coronavirus disease, scientists are at the forefront, with two vaccine trials from different labs showing encouraging results against the novel virus. The two potential vaccines from China and UK give hope that our pandemic ridden world can be saved but there is still a long way to go.

Two coronavirus vaccine candidates have proven safe for humans and produced strong immune reactions among patients involved in two separate clinical trials, doctors said Monday.

The first trial among more than a thousand adults in Britain found that the vaccine induced “strong antibody and T cell immune responses” against the novel coronavirus.

A separate trial in China involving more than 500 people showed most had developed widespread antibody immune response.

New vaccines to the rescue?

The studies, published in The Lancet medical journal, constitute a major step on the road towards a COVID-19 vaccine that is effective and safe for widespread use.

The authors of the studies said they encountered few adverse side effects from the vaccine candidates.

Read more: Coronavirus Pandemic: This is why prevention is better than Cure

They did, however, caution that more research was needed, particularly among older adults, who are disproportionately at risk of dying of COVID-19.

Co-author Sarah Gilbert from the University of Oxford said the results “hold promise”.

“If our vaccine is effective, it is a promising option as these types of vaccine can be manufactured at large scale.”

UK’s Oxford team pilots coronavirus vaccine trials

The pandemic has seen an unprecedented mobilisation of funding and research to rush through a vaccine that can protect billions of people worldwide.

More than 20 candidate vaccines are currently being tested on humans.

Read more: People on steroids may be more at risk of COVID-19

Both studies were phase-2 trials, which test whether the vaccine provokes an immune response and can be well tolerated by patients.

For its trial, the team at Oxford used a genetically modified strain of the common cold virus that infects chimpanzees.

They manipulated the virus to train cells to recognise the viral spike protein, which helps teach the immune system to recognise COVID-19.

As well as developing antibodies in their blood, patients given the vaccine were found to have developed a robust T cell response — helping their body identify and neutralise the virus.

“The immune system has two ways of finding and attacking pathogens — antibody and T cell responses,” said Andrew Pollard, a member of the Oxford team.

“This vaccine is intended to induce both, so it can attack the virus when it’s circulating in the body, as well as attacking infected cells.”

The Oxford team found that among the 500 or so patients given a single dose of the vaccine — developed jointly with pharmaceutical giant AstraZeneca — their immune response peaked around 14 days and decreased slightly by day 56, the end of the study period.

The other 500 patients were instead given a meningitis vaccine as a placebo.

Still a long way to go from trial to mass produced coronavirus vaccine

The second trial, led by China’s Jiangsu Provincial Center for Disease Control and Prevention, used a weakened human cold virus modified to deliver genetic material that teaches cells to recognise the novel coronavirus.

Read more: China starts developing another vaccine against the novel coronavirus

Two groups of patients were given either a high or low dose of the vaccine.

More than 90 percent of people in both groups showed either antibody or T cell immune responses between 14-28 days post vaccine.

Side effects in both trials were moderate but authors of the Chinese study said they needed to test the vaccine safety on older patients.

“Elderly people… are an important target population for a COVID-19 vaccine,” said Wei Chen, from the Beijing Institute of Biotechnology.

“It is possible that an additional dose may be needed in order to induce a stronger immune response in the elderly population.”

Both studies found severe side effects from the vaccine to be rare.

Read more: Bill Gates says world population should be injected with COVID-19 vaccine

Jonathan Ball, professor of molecular virology at the University of Nottingham, said that while the two vaccines were encouraging, he cautioned there was “a long way to go”.

“It is unclear whether the levels of immunity can protect against infection — that’s what the larger ongoing phase-3 trials are designed to test,” said Ball.

“Nor do we know if this vaccine can protect those most vulnerable to severe COVID-19 disease.”

There are currently a number of treatments available for patients hospitalised with COVID-19.

Last month a Britain-based team of researchers lead by the University of Oxford announced they had successfully reduced the risk of death among seriously ill patients by administering the commonly available steroid dexamethasone.

Several countries have also issued the emergency authorisation for treatment with anti-viral remdesivir.

AFP with additional input by GVS News Desk