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Thursday, May 23, 2024

How fasting may prevent diabetes?

"The timing of and duration between meals could be important factors to consider for people struggling with obesity-related conditions", says the lead author of the study.

News Desk |


The health benefits of fasting have been the subject of much hype in recent years. More and more people now fast, not just for religious purposes but also to lose weight and boost metabolism. Restricting food intake may increase metabolic activity more than researchers used to believe, studies suggest, and the practice may even help fight ageing.


Fasting may also improve gut health, according to other research, and strengthen circadian rhythms (daily sleep-wake cycles), thus boosting overall health. New research adds to this body of evidence by zooming in on a specific type of fasting and its benefits for obesity-related conditions.

Read more: Non-insulin drugs for treating type 2 diabetes

Dr. Ayse Leyla Mindikoglu, who is an associate professor of medicine and surgery at Baylor College of Medicine in Houston, TX, and her colleagues used the Islamic spiritual practice of Ramadan to study the benefits of fasting from dawn to sunset. The researchers found that practicing this type of fasting for 30 days raised the levels of certain proteins that can improve insulin resistance and stave off the adverse effects of a diet rich in fats and sugar.


Dr. Mindikoglu and team presented their findings at the Digestive Disease Week, a conference that took place recently in San Diego, CA. Dr. Mindikoglu and colleagues studied 14 people who were healthy at baseline and who fasted for 15 hours each day from dawn to sunset as part of Ramadan.

Read more: Type 2 diabetes patients show higher risk of liver cancer

While fasting, the participants did not consume any food or drink. Before the start of the fast, the researchers took blood samples from the participants. The scientists also tested the participants’ blood after 4 weeks of fasting and 1 week after fasting ended.

The blood samples revealed higher levels of proteins called ‘tropomyosin (TPM) 1, 3, and 4’. In layman terms, TPM is “best known for its role in the regulation of contraction of skeletal muscle and the heart.” However, it is also key for maintaining the health of cells that are important to insulin resistance and repairing them if they sustain damage.

TPM3, specifically, plays an important role in improving the body’s sensitivity to insulin. Better insulin sensitivity means better blood sugar control. And to apply that in practicality, one should trust the study’s lead author’s comments on the findings, “Feeding and fasting can significantly impact how the body makes and uses proteins that are critical to decreasing insulin resistance and maintaining a healthy body weight.”