Flexible DNA: Is it deeply linked to the human psyche?

New research indicates that a person's ability to overcome fear may be linked to the ability of his/her DNA to adapt and overcome fearful memories. Light is also shed on the elusive Z-DNA and its link with genes which may open more avenues for medicinal/health purposes.

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New research in mice suggests that when the DNA allows it, the brain neutralizes fearful memories using ‘fear extinction.’ The flexibility of a person’s DNA structure may correlate with a ‘flexibility of memory,’ according to new research.

When confronted with danger, fear spurs a person into defensive actions. Indeed, researches credit human evolution to this very response. After all, humans steered clear of larger predators and manifest dangers which allowed them to proliferate and evolve further. Even today, researchers credit the famed “fight or flight” response to the fear mechanism.

While fear is invaluable as a survival mechanism, there is little reason for it to persist once a threat passes.

The brain neutralizes the memory of that feeling with something called “fear extinction.” This process involves a non-fearful memory with similar circumstances competing with the fear memory to try to suppress it.

A new study finds that the ability to neutralize fear depends on the flexibility of one’s DNA.

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“Fear memories need to be plastic. They can be very useful for survival, but they can also get in the way of normal functioning,” says Dr. Paul Marshall of the University of Queensland, Brisbane, Australia. He is the lead author of the study, which the team published in Nature Neuroscience.

How DNA may form other structures to erase fearful memories 

There is more than one way in which the strands in DNA’s well-known double-helix structure may twist.

“The most common and most widely recognized form is the ‘B-DNA’ double helix, which twists in a clockwise direction,” says Marshall. “But, with a slight rearrangement of how DNA base-pairs connect with one another, DNA can form other helical structures, such as Z-DNA.”

To understand how this can happen, the researcher offers the following explanation: hold out the hands, palms down, so that the thumbs touch. In this position, the thumbs represent the bases of two DNA strands — and this is how they connect in the B-DNA structure.

Now move the pinkies downward, twisting the wrists so that the thumbs spread apart, the palms face up, and the pinkies touch — this simulates a Z-DNA twist. Continuing to twist the wrists so that the back of the hands face each other and the thumbs once again touch would represent a full twist back into a B-DNA position.

All about Z-DNA: the missing piece of the human genome puzzle?

Z-DNA forms less frequently than B-DNA, and only for specific sequences and over a short region. Only recently have scientists begin to figure out why it exists at all.

“We now know that Z-DNA appears wherever genes are being turned on,” says Marshall. He adds, “It’s a marker of gene activity.”

This structure appears to have something to do with memory. “Scientists have also noticed a connection between Z-DNA and certain diseases, including cancer, and high levels of Z-DNA have been found in the brains of people who had Alzheimer’s Disease,” Dr. Marshall says.

Earlier, in 2019, Dr. Alan Herbert had identified Z-DNA and its resultant structures as holding the ability to deactivate the immune system. This discovery was touted as the next frontier in understanding and ultimately curing cancer.

This discovery further sheds light on Z-DNA, which has long been an elusive domain for researchers.

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Dr. Marshall and senior author Prof. Tim Bredy became intrigued by the brief periods during which Z-DNA structures exist, perhaps because it suggested a possible correspondence with the rapid changes in gene activity seen during the creation of fear-extinction memories.

Online Int’l News with additional input by GVS News Desk